Ace inhibitors
Trovati 111 articoli
- Management of patients with diabetes mellitus
- The treatment of patients with diabetes mellitus should be based, wherever possible, on the results of studies of substantial size and duration that measure outcomes that are meaningful to patients. While treatment of hypertension and hyperlipidaemia reduce progression of micro-vascular disease,... (Leggi Articolo)
- Autoimmune disease: cardiovascular benefits of anti-TNF therapy in rheumatoid arthritis
- A chronic autoimmune disease, rheumatoid arthritis is characterized by persistent inflammation of the synovial membrane and progressive joint destruction. Beyond loss of mobility, sufferers face a high risk of heart failure. An inflammatory cytokine known for contributing to the development of ... (Leggi Articolo)
- Benign prostatic hyperplasia: 5-alpha reductase inhibitors not associated with increased risk of hip fracture
- Use of a class of medications for treating an enlarged prostate, known as 5-alpha reductase inhibitors, are not associated with an increased hip fracture risk. Benign prostatic hyperplasia ( BPH ) is a common condition in aging men. It has been estimated that more than 8 million United States ... (Leggi Articolo)
- Breast tumor: Femara treatment beginning long after stopping Nolvadex still offers preventive benefits
- Treatment with the aromatase inhibitor Letrozole ( Femara ) can reduce the risk of breast cancer recurrence even when initiated one to seven years after a course of Tamoxifen therapy. The results of a study involving women originally in the placebo arm of an international trial of Letrozole are p... (Leggi Articolo)
- Lipitor, interactions and the risk of haemorrhagic stroke in patients with recent stroke
- Pfizer has informed Healthcare Professional of updated prescribing advice for Atorvastatin ( Lipitor ). The new advice relates to interactions and the risk of haemorrhagic stroke in patients with recent stroke. Interactions with other medicines Atorvastatin levels may increase when administ... (Leggi Articolo)
- TACE, a new target for the treatment of breast cancer
- Researchers have demonstrated that inhibiting the activity of the protease enzyme known as TACE can deprive tumor cells of a key factor needed for their proliferation. TACE is strongly present in a form of breast cancer which responds poorly to current therapies. " We have shown that inhibitio... (Leggi Articolo)
- Sartans and Ace inhibitors not recommended during pregnancy
- Ace ( angiotensin converting enzyme ) inhibitors and sartans ( also called angiotensin II receptor antagonists ) are licensed for various indications, including hypertension, and may be particularly suitable for young patients with high blood pressure ( but not those of black ethnic origin ) and... (Leggi Articolo)
- Aromatase inhibitors linked to increase in survival in advanced breast cancer
- Aromatase inhibitors, a type of hormone therapy used to treat advanced breast cancer in postmenopausal women, result in a small but significant increase in overall survival when compared to other hormone treatments, according to a new systematic review of studies. In addition, aromatase inhib... (Leggi Articolo)
- Several serious reactions linked to TNF-alpha inhibitors
- Tumour necrosis factor alpha ( TNF-alpha ) is a cellular protein produced by the immune system and is an important mediator of many diseases, including inflammatory arthritis and inflammatory bowel disease. Currently, three tumour necrosis factor alpha blocking agents are registered in Australi... (Leggi Articolo)
- ADRAC: drug-induced pancreatitis
- Gallstones and alcohol are the two most common causes of pancreatitis, but medicines are estimated to account for about 2 to 5% of cases. ADRAC ( Adverse Drug Reactions Advisory Committee ) has received 414 such reports, implicating 695 medicines. Time to onset varied from the first day of use t... (Leggi Articolo)
- Serious health problems associated with blocking angiogenesis signaling from inside cell
- Angiogenesis inhibitors that block a tumor’s development of an independent blood supply have been touted as effective cancer fighters that result in fewer side effects than traditional chemotherapy. However, a new study by researchers at UCLA’s Jonsson Cancer Center showed that one method of blo... (Leggi Articolo)
- Increased blood concentrations of Zanaflex with concomitant use of CYP1A2 inhibitors
- Acorda Therapeutics anf FDA ( Food and Drug Administration ) have informed that concomitant use of Tizanidine ( Zanaflex ) with Fluvoxamine ( Luvox ) or Ciprofloxacin ( Cipro ), potent CYP1A2 inhibitors, is contraindicated. The interaction between Tizanidine and either Fluvoxamine or Ciproflox... (Leggi Articolo)
- Candesartan reduces the incidence of major adverse cardiovascular events in patients with impaired renal function
- Researchers conducted the HIJ-CREATE ( The Heart Institute of Japan-Candesartan Randomized trial for Evaluation in Coronary Artery Disease ) trial to determine whether the angiotensin II receptor blocker ( ARB ) Candesartan ( Atacand, Ratacand ) would reduce cardiovascular events more than angiot... (Leggi Articolo)
- Revised guidelines for unstable angina and non-ST-elevation myocardial infarction
- The American College of Cardiology ( ACC ) and the American Heart Association ( AHA ) have jointly released revised Guidelines for the Management of Patients with Unstable Angina and Non-ST-Elevation Myocardial Infarction. Major changes to the guidelines include: suggesting an initial non-invas... (Leggi Articolo)
- Post-traumatic stress disorder: effectiveness of most therapies is uncertain
- Many people, including significant proportions of active duty military personnel and veterans, suffer from post-traumatic stress disorder ( PTSD ), often in conjunction with other injuries or illnesses. While several drugs and psychotherapies are used to treat PTSD, many of the studies concerning... (Leggi Articolo)
- Selective COX-2 inhibitors linked to risk of myocardial infarction
- Researchers at University of Manchester, UK, evaluated the risk of myocardial infarction associated with the use of selective cyclooxygenase-2 ( COX-2 ) inhibitors ( coxibs ). A systematic review and meta-analysis of randomised controlled trials ( RCT s) were performed. Fifty-five trials ( 9... (Leggi Articolo)
- Efficacy and adverse effects of cholinesterase inhibitors and Namenda in vascular dementia
- A systematic review and meta-analysis evaluated the efficacy and safety of cholinesterase inhibitors and Memantine ( Ebixa, Namenda ) in vascular dementia. Three Donepezil ( Aricept ), two Galantamine ( Reminyl ), one Rivastigmine ( Exelon ), and two Memantine trials, comprising 3093 patients ... (Leggi Articolo)
- Belimumab improves symptoms in 46 percent of systemic lupus erythematosus patients
- Treatment with Belimumab resulted in a sustained improvement of systemic lupus erythematosus ( SLE or lupus ) disease activity in 46% of patients at week 52. Historically, it has been difficult to adequately measure the therapeutic responses to drug intervention in SLE patients, due to the div... (Leggi Articolo)
- No advantage for Zonegran in refractory partial epilepsy
- Zonisamide ( Zonegran ) is a sulphonamide derivative that inhibits carbonic anhydrase; it resembles Topiramate ( Topamax ). The main clinical trial, a double-blind study lasting 36 weeks, compared the addition of Zonisamide or placebo to ongoing treatment in 351 patients with refractory partia... (Leggi Articolo)
- DPP-4 inhibitors: Novartis has improved Galvus risk/benefit profile
- Novartis has provided a safety update to European regulators of pooled data showing numerically less frequent liver enzyme elevations in patients who took either 50 mg per day or 50 mg twice daily of Galvus ( Vildagliptin ) compared to 100 mg once-daily. As a result, Novartis has proposed changes... (Leggi Articolo)
- Lumiracoxib linked to tisk of hepatotoxicity
- Prexige is a selective COX-2 inhibitor in the class of drugs called NSAIDs ( non-steroidal anti-inflammatory drugs ). In New Zealand, Novartis has informed Health Care Professionals of important new safety information about serious liver side effects mainly observed with chronic use of doses ... (Leggi Articolo)
- Acute coronary syndrome: recommended treatments linked with reductions in rates of heart failure, stroke, heart attack and death
- Recent changes in the recommended treatments used for patients hospitalized for acute coronary syndromes are associated with reductions in the rates of heart failure, stroke, myocardial infarction and death. Randomized trials have provided strong evidence for the effectiveness of pharmacologic... (Leggi Articolo)
- The endocannabinoid system as an new target of pharmacotherapy
- The endocannabinoid system was discovered through research into delta 9-tetrahydrocannabinol ( 9-THC ), the active ingredient in cannabis. The endocannabinoid system consists of cannabinoid receptors, endogenous cannabinoids ( endocannabinoids ), and the enzymes that synthesize and degrade end... (Leggi Articolo)
- Dormant inflammatory bowel disease: painkillers effective
- Two studies, published in the Clinical Gastroenterology and Hepatology, have showen that prescription painkillers are effective in easing the pain of patients with dormant inflammatory bowel disease ( IBD ) and are not likely to cause symptom flare-ups in IBD patients in remissions. Both studi... (Leggi Articolo)
- Relationship between inflammatory processes and tumor formation
- Researchers are closely studying the link between inflammatory processes and tumor formation, while others are investigating anti-inflammatory drugs as a means to prevent and treat cancer. Antihistamine and anti-inflammatory drug use associated differently for high-grade versus low-grade gli... (Leggi Articolo)
- Hypertension: Rasilez provides dose-dependent efficacy
- Aliskiren ( Rasilez, Tekturna ) is the first in a new class of orally-administered rennin inhibitors, and is under investigation for the treatment of hypertension. Renin is an enzyme released by specialized cells of the kidney into the blood. It is in response to sodium depletion or low blood ... (Leggi Articolo)
- New evidence on risks associated with Cox-2 inhibitors and NSAIDs
- Two review studies evaluating the safety of the selective cyclooxygenase 2 ( COX-2 ) inhibitors and non-steroidal anti-inflammatory drugs ( NSAIDs ) have found increased cardiovascular and kidney risks. It is estimated that more than 30 million people worldwide take NSAIDs daily for treatment ... (Leggi Articolo)
- COX-2 inhibitors reduce risk of cancer
- Results from a five-year study have shown that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers. " We believe this is the first study to show that sel... (Leggi Articolo)
- Januvia reduces blood glucose levels in monotherapy or as add-on treatment in patients with type 2 diabetes
- Phase III studies demonstrated that Sitagliptin ( Januvia ), an investigational oral, once-daily medicine for type 2 diabetes, significantly reduced blood glucose levels when used as monotherapy or as an add-on treatment to two commonly used therapies ( Metformin or Pioglitazone ). Additionally... (Leggi Articolo)
- HIV infection: ethnic differences in response to HAART
- Researchers from the University of Massachusetts and the University of Pennsylvania have shown that race/ethnicity is a predictor of plasma lipids in patients with HIV-1 on HAART ( Highly Active AntiRetroviral Therapy ). The researchers, led by Andrea Foulkes and Muredach Reilly, examined the ... (Leggi Articolo)
- ACE inhibitors linked to increased risk of birth defects during the first trimester of pregnancy
- A study, led by William Cooper, at the Monroe Carell Jr. Children's Hospital at Vanderbilt University Medical Center, found infants born to mothers who took angiotensin converting enzyme inhibitors ( ACE inhibitors ) during the first trimester of pregnancy had an increased risk of major birth def... (Leggi Articolo)
- Vardenafil may protect the heart following acute myocardial infarction
- Researchers at Virginia Commonwealth University ( VCU ) found that Levitra ( Vardenafil ), an erectile dysfunction drug, protects the heart against tissue damage following acute myocardial infarction. " Our findings further support the concept that the novel class of phosphodiesterase-5 inhi... (Leggi Articolo)
- Secondary prevention: only 71 percent of patients with coronary artery disease uses Aspirin
- Researchers at the Duke Clinical Research Institute have determined that there is still much need for better physician prescribing of, and patient adherence to, life-saving medicines, particularly continued long-term use of cardiovascular medicines. The most glaring example highlighted by the... (Leggi Articolo)
- FDA: Selegiline is the first transdermal patch for depression
- The FDA ( Food and Drug Administration ) approved Emsam ( Selegiline ), the first transdermal patch for use in treating major depression. The once a day patch works by delivering Selegiline, a monoamine oxidase inhibitor or MAOI, through the skin and into the bloodstream. At its lowest stre... (Leggi Articolo)
- Positive results for a novel oral HIV integrase inhibitor
- The data from a phase I/II study showed significant reductions in viral load among HIV-positive patients receiving GS 9137, or JTK-303, a novel oral HIV integrase inhibitor, as monotherapy or in combination with ritonavir as a boosting agent, compared to placebo. Integrase inhibitors are a ne... (Leggi Articolo)
- Genetics plays a role in the side effects experienced by patients taking COX-2 inhibitors
- A study published in the journal Gastroenterology found a difference in how people responded to COX-2 inhibitors and that up to 30 percent of this variability can be attributed to an individual's genetic make-up. This variation can influence both how useful the drugs are in affording relief fro... (Leggi Articolo)
- Activation of microRNA inhibits cancer gene in human cancer cells
- Researchers have reported that tumor cells display a dramatic reduction of cancer-causing genes when a newly discovered method is used to activate the expression of protective microRNAs in the cancer cell genome. The research has demonstrated that agents known to regulate gene expression can ... (Leggi Articolo)
- Selective inhibition of pathological form of AMPA receptor could protect vulnerable neurons in stroke
- In the stroke, researchers have traced the major cause of the death of brain cells due to artery blockage or bleeding in the brain. They know that the resulting oxygen loss, or ischemia, unleashes a cascade of the brain chemical glutamate, which in turn triggers receptors on the surface of brai... (Leggi Articolo)
- Stroke prevention in patients with non-valvular atrial fibrillation
- Clinical trials comparing antithrombotic therapy with placebo have shown that Warfarin ( Coumadin ) reduces the risk of stroke by 62%, and that Acetylsalicylic acid ( ASA, Aspirin ) alone reduces the risk by 22%. In high-risk patients, Warfarin is superior to Acetylsalicylic acid in preventi... (Leggi Articolo)
- Seasonal influenza: neuraminidase inhibitors should not be used as routine
- Neuraminidase inhibitors are recommended for use against influenza and its complications in interpandemic years and in a pandemic. Researchers assessed the effects of neuraminidase inhibitors in preventing or ameliorating influenza, its transmission and its complications in healthy adults and ... (Leggi Articolo)
- Groovy protein essential for promoting cancer development
- Researchers have determined the detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast majority of human cancers. Understanding the physical shape of the protein has led to a better understanding of how it acts to immortalize cells – and should h... (Leggi Articolo)
- p11 appears to help regulate signaling of the brain messenger chemical serotonin
- A protein that seems to be pivotal in lifting depression has been discovered by Paul Greengard. " Mice deficient in this protein, called p11, display depression-like behaviors, while those with sufficient amounts behave as if they have been treated with antidepressants," explained Paul Greenga... (Leggi Articolo)
- ERK pathway: potential target for new pain therapies
- Studying mice, researchers at Washington University School of Medicine in St. Louis have identified two key components in the pain cascade that may provide targets for more effective analgesic drugs with potentially fewer side effects. A team led by Robert W. Gereau IV, reported in the journa... (Leggi Articolo)
- FDA has approved Vorinostat for cutaneous T-cell lymphoma
- The FDA ( Food and Drug Administration ) has approved Zolinza ( Vorinostat, also known as SuberoylAnilide Hydroxamic Acid, SAHA) ) capsules for the treatment of advanced cutaneous T-cell lymphoma ( CTCL ), a type of skin cancer. Zolinza is the first in a new class of anti-cancer therapies call... (Leggi Articolo)
- Alzheimer's drugs: Aricept, Exelon and Razadyne offer modest improvements, equal effectiveness
- The Alzheimer's drugs Aricept ( Donepezil ), Razadyne ( Galantamine ) and Exelon ( Rivastigmine ) can lead to small improvements in mental functioning and the ability to carry out everyday activities in people with mild to moderate forms of the disease, according to a review of recent studies. ... (Leggi Articolo)
- Zolinza in patients with advanced, refractory cutaneous T-cell lymphoma
- A pivotal Phase IIb open-label study evaluated Vorinostat ( Zolinza ) in patients with advanced, refractory cutaneous T-cell lymphoma ( CTCL ). In the study, 30 percent of the patients ( 22 of 74 ) responded to treatment with Vorinostat as measured by the objective response rate. The single... (Leggi Articolo)
- Statins, beta-blockers lessen myocardial infarction risk
- A research from the Stanford University School of Medicine suggests that statins and beta-blockers can steer patients away from having a myocardial infarction toward the less serious symptom of mild chest pain that occurs only with exercise ( angina ). The study, published in the Annals of Int... (Leggi Articolo)
- HIV infection: Atripla more effective and better tolerated than traditional combination of antiretrovirals
- Researchers at Johns Hopkins and other institutions has found that a once-daily combination of three antiretroviral drugs works better as an initial treatment for HIV infection than another three-drug combination long considered the gold standard. Reporting in the The New England Journal of M... (Leggi Articolo)
- Stem cells with myelin inhibitors may help paralyzed rats recover
- A therapy that combines differentiated stem cells with myelin inhibitors and a motor axon tropic factor helped paralyzed rats restore functional motor units and gain some physical recovery. " This is the first report, to our knowledge, of the anatomical and functional replacement of a motor ne... (Leggi Articolo)
- Basic research at the Max Planck Institute of Biochemistry leads to a novel cancer therapy
- Axel Ullrich, at the Max Planck Institute of Biochemistry in Martinsried, Germany, already showed at the beginning of the 1990s that blocking blood vessel development in a tumour slows down its growth, and shrinks its tissue. This fundamental principle led to the development of Sutent ( Sunit... (Leggi Articolo)
- SSRI antidepressants may also affect human immune system
- Researchers from Georgetown University Medical Center and a Canadian research institute fpund that drugs that treat depression by manipulating the neurotransmitter serotonin in the brain may also affect the user's immune system in ways that are not yet understood. That's because the investigato... (Leggi Articolo)
- Sprycel circumvents Glivec resistance in chronic myeloid leukemia
- Dasatinib ( Sprycel ) reverses the signs and symptoms of patients whose chronic myeloid leukemia has failed to respond to Imatinib ( Gleevec / Glivec ), which is considered the standard of treatment for the disorder. In a study published in The New England Journal of Medicine ( NEJM ), Howard... (Leggi Articolo)
- Nexium maintains normal acid production in Zollinger-Ellison syndrome
- A study has shown that the proton pump inhibitor Esomeprazole ( Nexium ) maintains normal gastric acid levels in patients with Zollinger-Ellison syndrome or idiopathic gastric acid hypersecretion. Twenty-one patients received one of several doses of Esomeprazole, depending on the degree of the... (Leggi Articolo)
- Increased risk for heart disease and stroke in older people with high blood pressure and kidney disease
- Older people with high blood pressure and moderate to severe chronic kidney disease have a greater chance of developing heart disease than people with normal kidney function. The study, published in the Annals of Internal Medicine, also found these patients are at higher risk for developing h... (Leggi Articolo)
- Antidepressants linked to increased risk of death for patients with coronary artery disease
- Researchers at Duke University Medical Center have found that patients with coronary artery disease who take commonly used antidepressant drugs may be at significantly higher risk of death. Even after controlling for such factors as age, degree of heart disease and severity of depression, the... (Leggi Articolo)
- ACCP guidelines: many OTC medications not recommended for cough treatment
- New guidelines issued by the American College of Chest Physicians ( ACCP ) provide the most comprehensive recommendations for the diagnosis and management of cough in adults and children, including specific recommendations for the prevention of whooping cough in adults. Diagnosis and Managemen... (Leggi Articolo)
- Antidepressant use during pregnancy appears associated with withdrawal symptoms in newborns
- A study, published in the Archives of Pediatrics & Adolescent Medicine, showed that almost one-third of 60 newborn infants whose mothers took antidepressants during pregnancy experienced neonatal abstinence syndrome, a type of withdrawal with symptoms that include high-pitched crying, tremors and... (Leggi Articolo)
- Breast cancer: breast-sparing surgery an option for women with BRCA mutations
- The women diagnosed with breast cancer who carry a certain genetic mutation can have breast-sparing surgery but should consider hormonal treatments to reduce their risk of cancer returning. A 10-year study, led by researchers at the University of Michigan, found that women with the genetic muta... (Leggi Articolo)
- Clinical Performance Measures focuses on the most critical steps in the treatment of patients with myocardial infarction
- Myocardial infarction strikes some 865,000 Americans each year. Treating patients with scientifically proven therapies both in the hospital and at home can markedly increase the chances of survival and a return to an active life. To aid physicians in achieving this therapeutic goal, the America... (Leggi Articolo)
- Januvia in the treatment for diabetes mellitus type 2
- Results from three Phase II studies showed that Sitagliptin ( Januvia ), an investigational medicine in a potentially new class of agents for the treatment for diabetes called DPP-IV ( dipeptidyl peptidase IV ) inhibitors significantly improved glycemic control in patients with type 2 diabetes c... (Leggi Articolo)
- Estrogen deprivation and joint pain
- Women treated with aromatase inhibitors often experience joint pain and musculoskeletal aching --severe enough, in some cases, to make them stop the treatment. Two researchers, David T. Felson, of Boston University Clinical Epidemiology Unit, and Steven R. Cummings, of California Pacific Medi... (Leggi Articolo)
- Europe: Pfizer suspends sales of Bextra
- Following discussions with the European Medicines Agency ( EMEA ), Pfizer has agreed to the suspension of use of anti-inflammatory drug, Bextra ( Valdecoxib ), in Europe as an interim measure pending finalisation of the assessment of COX-2 inhibitors. Pfizer has agreed to similar actions in th... (Leggi Articolo)
- Health Canada: safety of Cox-2 selective NSAIDs, report of the Expert Advisory Panel
- Cox-2 selective inhibitors are used to relieve pain resulting from a variety of musculoskeletal disorders. Numerous studies have shown that their effectiveness in pain relief is similar to "traditional" nonsteroidal anti-inflammatory drugs ( NSAIDs ), although some patients seem to respond prefe... (Leggi Articolo)
- Nexium may reduce upper GI symptoms in patients using NSAIDs
- Results from two clinical trials demonstrate that Esomeprazole ( Nexium ) can reduce upper gastrointestinal ( GI ) symptoms - such as moderate to severe pain, burning and discomfort in the upper abdomen - associated with continuous, daily use of non-steroidal anti-inflammatory drugs ( NSAIDs ), i... (Leggi Articolo)
- Aripiprazole IM in patients with acute bipolar mania and schizophrenia
- In two double-blind, randomized, multicenter studies evaluated the investigational use of intramuscular ( IM ) Aripiprazole ( Abilify ) in patients with either acute bipolar mania or schizophrenia. The primary efficacy measure for both studies was mean change from baseline to two hours post-i... (Leggi Articolo)
- Cox-2 inhibitors: prescribing restrictions for all drugs
- After evaluation of the available data, and consideration of submissions from patients and health professionals, the Medicines Adverse Reactions Committee ( MARC ) has recommended that the COX-2 inhibitors Celecoxib ( Celebrex ), Etoricoxib ( Arcoxia ), Lumiracoxib ( Prexige ), Meloxicam ( Mobic ... (Leggi Articolo)
- Ruboxistaurin shows favorable effects in type 2 diabetes and diabetic nephropathy
- A one-year pilot study examined the effect of Ruboxistaurin ( Arxxant ) in patients with type 2 diabetes and diabetic nephropathy. Data showed that in patients being treated with angiotensin converting enzyme inhibitors ( ACE inhibitors ), angiotensin receptor blockers ( ARBs ), or both, Rubox... (Leggi Articolo)
- Anti-inflammatory drugs: COX-2 inhibitors associated with blood pressure elevation
- An analysis of 19 randomized controlled trials involving COX-2 inhibitors ( selective cyclooxygenase-2 inhibitors ) suggests that these agents raise blood pressure more than either conventional nonsteroidal anti-inflammatory drugs ( NSAIDs ) or placebo. NSAIDs, among the most widely prescribed... (Leggi Articolo)
- Heart failure, patients at greatest risk of death least likely to receive appropriate medications
- Heart failure is associated with a high death rate. Medications shown to reduce the risk of illness and death from this condition include angiotensin-converting enzyme ( ACE ) inhibitors, angiotensin II receptor blockers ( ARBs ), and beta-adrenoreceptor antagonists. These drug classes have bee... (Leggi Articolo)
- Advanced lung cancer, Tarceva extends survival
- A study, led by Canadian researchers, has demonstrated that Erlotinib ( Tarceva ) increases survival in patients with advanced non-small cell lung cancer who typically have no other treatment options. The trial, funded by the Canadian Cancer Society and published in The New England Journal of... (Leggi Articolo)
- Type 2 diabetes: Pioglitazone reduces myocardial infarctions, strokes and deaths
- Data from the PROactive Study, presented at the 41st meeting of the European Association for the Study of Diabetes ( EASD ) in Athens, demonstrated that Actos ( Pioglitazone ) significantly reduces the combined risk of heart attacks, strokes and death by 16% in high risk patients with type 2 di... (Leggi Articolo)
- Diuretics effective for people with diabetes and high blood pressure
- The "Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial " or ALLHAT shows that in people with diabetes, diuretics work as well as ACE-inhibitors and calcium channel blockers in protecting against heart attack and improving survival, and offer more protection against cong... (Leggi Articolo)
- FDA approves BiDil in black patients with heart failure
- FDA ( Food and Drug Administration ) approved BiDil ( Isosorbide dinitrate/Hydralazine hydrochloride ) for the treatment of heart failure in black patients. BiDil is indicated to improve survival, prolong time to hospitalization for heart failure and improve patient-reported functional status... (Leggi Articolo)
- Aripiprazole for maintaining efficacy in bipolar I disorder
- The U.S. FDA ( Food and Drug Administration ) approved Aripiprazole ( Abilify ) for maintaining efficacy in patients with bipolar I disorder with a recent manic or mixed episode who had been stabilized and then maintained for at least six weeks. This new, expanded, indication is based on the ... (Leggi Articolo)
- Diuretics work better than newer therapies in hypertension
- Thiazide-type diuretics remain the drugs of choice for initial therapy of high blood pressure in both black and non-black patients. Death related to hypertension and the risk of end-stage renal disease ( ESRD ), coronary heart disease ( CHD ), heart failure ( HF ), and stroke are increased in... (Leggi Articolo)
- Tekturna: a novel renin inhibitor in hypertension
- Aliskiren ( Rasilez, Tekturna ) is the first in the new class of antihypertensive agents, called renin inhibitors. Suppression of the renin angiotensin system ( RAS ) using angiotensin converting enzyme ( ACE ) inhibitors and angiotensin II receptor blockers ( ARB ) has widely shown to treat h... (Leggi Articolo)
- FDA has approved Aceon to reduce risk of cardiovascular mortality or non-fatal myocardial infarction in patients with stable coronary artery disease
- FDA ( Food and Drug Administration ) has approved Aceon ( Perindopril erbumine ) tablets for the treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or non-fatal myocardial infarction. Prior to this labeling expansion, Aceon was indicated fo... (Leggi Articolo)
- ACE inhibitors work less well in black patients with high blood pressure
- Diuretics work better than newer therapies in treating high blood pressure and reducing risk of heart disease in both black and non-black patients, according to a long-term, multicenter trial of antihypertensive therapies funded by the National Heart, Lung, and Blood Institute ( NHLBI ) of the Na... (Leggi Articolo)
- Adderall XR, as a once-daily treatment for adolescents aged 13 to 17 with ADHD
- FDA ( Food and Drug Administration ) has approved Adderall XR ( mixed salts of a single-entity amphetamine product ) as a once-daily treatment for adolescents aged 13 to 17 with attention deficit hyperactivity disorder ( ADHD ). Since October 2001, Adderall XR has been approved in the U.S. for... (Leggi Articolo)
- Integration of cell survival signals in PTEN-deficient tumors
- A study has identified a molecular switch that integrates cell survival signals from multiple intracellular signaling pathways. The finding has substantial clinical significance, as mutations in these cell survival-signaling pathways are associated with many human cancers, and a better underst... (Leggi Articolo)
- FDA has approved Atacand for the treatment of heart failure
- AstraZeneca announced that the US Food and Drug Administration (FDA) has approved its angiotensin receptor blocker (ARB) Candesartan Cilexetil ( Atacand ) for the treatment of heart failure ( NYHA II-IV and ejection fraction less than or equal to 40 percent) to reduce the risk of death from cardi... (Leggi Articolo)
- Diastolic heart failure: statins may lower mortality
- Cardiologists at Wake Forest University Baptist Medical Center demonstrated statin therapy may improve survival in patients with diastolic heart failure ( DHF ). The study has been published in Circulation, journal of the American Heart Association. Currently, there are no treatments show... (Leggi Articolo)
- Notch signaling molecule important in type 2 immunity
- Defects in immune system cells called T helper cells may lead to diseases characterized by a faulty inflammatory response such as autoimmunity and asthma. Helper T cells differentiate into two different types of cells –Th1 or Th2 – which are responsible for regulating immunity to different typ... (Leggi Articolo)
- Low-dose Acetylsalicylic acid might prevent the cardiac damage of Cox-2 inhibitors
- An animal study, published in the journal Cell Metabolism, found that the increased rate of cardiovascular complications in patients taking the cox-2 inhibitor Rofecoxib ( Vioxx ) may result from a chemical imbalance. The findings suggest that low-dose Acetylsalicylic acid ( Aspirin ) might pr... (Leggi Articolo)
- Angioplasty, more experienced doctors linked to better outcomes
- In the most up-to-date analysis yet of this contentious issue, researchers from the University of Michigan Cardiovascular Center and the Blue Cross Blue Shield of Michigan Cardiovascular Consortium find that the risk of major complications from angioplasty and related procedures is much lower amo... (Leggi Articolo)
- Resetting epigenetic code could aid patients with systemic lupus erythematosus
- Researchers at Wake Forest University School of Medicine and the University of Virginia hope to reset part of the "epigenetic code" in lupus patients. The epigenetic research focuses on histones, the tiny spools in the nuclei of cells around which DNA winds and compacts when it is not in the p... (Leggi Articolo)
- Breast cancer, an aromatase inhibitor, Letrozole, improves survival for some patients, reduces metastasis
- The complete analysis of data from a trial of the drug Letrozole ( Femara ) confirms earlier reports that the drug reduced the recurrence of breast cancer in women previously treated with Tamoxifen ( Nolvadex ). It also finds that Letrozole prevents the development of metastases, even in wome... (Leggi Articolo)
- An acid-sensing cellular receptor might have clinical relevance in arthritis, heart attack, stroke
- Karin Westlund and Terry McNearney, at the University of Texas Medical Branch ( UTMB ) in Galveston, noted that " a neurogenic contribution to arthritis has long been appreciated with multiple case reports of arthritis sparing or reversing on the patient's paralyzed side after stroke or nerve inj... (Leggi Articolo)
- Eczema: Elidel in patients requiring an alternative to conventional steroid treatment
- A study has shown the importance of Elidel ( Pimecrolimus ) cream 1% as an alternative to topical corticosteroids. Elidel cleared eczema from the faces of patients allergic to or intolerant of steroids. The study found 46.5% of patients treated with Elidel after six weeks were clear or almost... (Leggi Articolo)
- APC study, cardiovascular risk associated with Celecoxib
- Adenoma Prevention with Celecoxib ( APC ) study investigators reviewed all potentially serious cardiovascular events among 2035 patients with a history of colorectal neoplasia who were enrolled in a trial comparing two doses of Celecoxib ( 200 mg or 400 mg twice daily ) with placebo for the preve... (Leggi Articolo)
- Llittle benefit from Aricept in progression from mild cognitive impairment to Alzheimer’s disease
- In a study of people with mild cognitive impairment ( MCI ), those who took the drug Donepezil were at reduced risk of progressing to a diagnosis of Alzheimer's disease (AD) during the first year of the trial, but by the end of the 3-year study there was no benefit from the drug. Vitamin E was... (Leggi Articolo)
- Cancer therapy: ABT-737, a promising new approach
- An experimental compound, ABT-737, that blocks the action of a class of proteins known as the Bcl-2 family, may prove to be a valuable tool in the fight against cancer. The Bcl-2 family of proteins plays a central role in regulating apoptosis and, consequently, in tumor formation, tumor growt... (Leggi Articolo)
- Elderly: narcotic drugs effective for severe, chronic pain
- Researchers at University of California San Francisco ( UCSF ) have compared younger versus older patients' desires / needs to escalate the dose of opioid pain medications they take -- a class of drugs including Morphine, Methadone and Oxycodone. Opioids have long been used for unremitting p... (Leggi Articolo)
- A combination with Bortezomib overcomes drug-resistant myeloma cells
- A novel strategy devised by Dana-Farber Cancer Institute scientists has proved highly effective in killing drug-resistant multiple myeloma cells in the laboratory. The researchers hope to move rapidly to clinical trials of the therapy, a combination of the drug Bortezomib ( Velcade ) and an ex... (Leggi Articolo)
- Three new genetic mutations in brain tumors identified
- Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors, a discovery that could pave the way for more effective cancer treatments. The Hopkins team, in conjunction with researchers at the J. Craig Venter Institute in Rockville, discovered DNA abnormalities in ... (Leggi Articolo)
- Increased risk for diarrhea infection with use of gastric acid-suppressive agents
- Use of gastric acid-suppressive therapy, particularly proton pump inhibitors, is associated with an increased risk for an infection that is a significant cause of diarrhea. Clostridium difficile infection, an important cause of nosocomial diarrhea, has also been reported to be an important cau... (Leggi Articolo)
- Blocking the nerve receptor EP1 reduces brain damage caused by stroke in mouse models
- Researchers at Johns Hopkins have discovered how to block a molecular switch that triggers brain damage caused by the lack of oxygen during a stroke. The Hopkins study, conducted on mice, is believed to be the first to demonstrate that a protein on the surface of nerve cells called the EP1 re... (Leggi Articolo)
- Vaginal gel protect the animals against an HIV-like virus
- Research with female monkeys at the Tulane National Primate Research Center has for the first time shown that three different anti-viral agents in a vaginal gel protect the animals against an HIV-like virus. The research suggests that a microbicide using compounds that inhibit the processes by... (Leggi Articolo)
- Aromatase inhibitors may slow growth of lung cancer in women
- A few years ago researchers discovered that, much like breast tumors, some lung tumors also thrive on estrogen. Now researchers at the Howard Hughes Medical Institute ( HHMI ) have managed to stop the growth of human lung cancer cells in mice with a class of breast cancer drugs called aromatase... (Leggi Articolo)
- Recurrent ischemic stroke: two biomarker, sVCAM-1 and NT-proBNP, in survivors may provide predictive information
- A study, published in the Archives of Neurology, showed that measurement of two biomarker levels in stroke survivors may provide predictive information for recurrent ischemic stroke beyond traditional risk factors. The two biomarkers are soluble vascular cell adhesion molecule 1 ( sVCAM-1 ) an... (Leggi Articolo)
- Aldosterone helps neurons survive after a stroke
- Despite better management of blood pressure – the number-one risk factor for strokes – stroke incidence is not declining and aging baby boomers likely will cause rates to spike, says Anne M. Dorrance, at Medical College of Georgia. She is among an increasing number of researchers who think the... (Leggi Articolo)
- Acetylsalicylic acid may reduce risk of colon tumor recurrence and death
- A study led by researchers at Dana-Farber found that Acetylsalicylic acid ( Aspirin ) has a potential treatment benefit in people who have colon cancer. The patients who took Aspirin regularly have a decreased risk of disease recurrence and death by half compared to non-users, after surgery. ... (Leggi Articolo)
- Excessive doses of antithrombotic therapy in patients with acute coronary syndromes
- A prospective observational analysis, coordinated by the DCRI ( Duke Clinical Research Institute ), in 387 US hospitals of 30,136 patients from the CRUSADE database has found that patients with NSTE ACS (non–ST-segment elevation acute coronary syndromes ) treated in the community often receive e... (Leggi Articolo)
- Multiple myeloma: FDA has approved Velcade as second-line
- The FDA ( Food and Drug Administration ) approved a supplemental New Drug Application ( sNDA ) for Velcade ( Bortezomib ). This approval expands the label to include the treatment of patients with multiple myeloma who have received at least one prior therapy. Bortezomib is the first in a ne... (Leggi Articolo)
- FDA: Diovan to reduce cardiovascular death in myocardial infarction survivors at high risk
- The FDA ( Food and Drug Administration ) approved Diovan ( Valsartan ), an ARB ( angiotensin receptor blocker ), for a new indication to reduce cardiovascular death in patients at high risk ( with left ventricular failure or left ventricular dysfunction ) following a heart attack. FDA also ex... (Leggi Articolo)
- Second-generation antidepressants very similar but have different side effects
- Many second-generation antidepressants, despite differences in drug classification and cost, offer patients essentially the same benefits with little variation in risks, University of North Carolina ( UNC ) at Chapel Hill researchers have found. Such antidepressants include selective serotonin... (Leggi Articolo)
- Elderly, non-hemophiliac, intracerebral hemorrhage patients: NovoSeven increases risk of arterial thromboembolic events
- Novo Nordisk and FDA ( Food and Drug Administration ) have notified HealthCare Professionals of revisions to the Warnings and Adverse Reactions sections of the prescribing information for NovoSeven ( recombinant coagulation Factor VIIa ) to provide updated safety information on thrombotic and thr... (Leggi Articolo)
- Breast cancer, treatment switch to Anastrozole after two years of Tamoxifen is beneficial
- A study, published in The Lancet, demonstrated that switching treatment to the drug Anastrozole ( Arimidex ) after two years of Tamoxifen ( Nolvadex ) can improve event-free survival for postmenopausal women with early breast cancer. For more than 20 years Tamoxifen has been the standard treat... (Leggi Articolo)
- Alzheimer’s disease: treatment with CDK5 inhibitors
- Researchers discovered three molecules that appear to inhibit a key perpetrator of Alzheimer's disease. Each of the three molecules protects the protein called "tau," which becomes hopelessly tangled in the brains of patients with Alzheimer's. Alzheimer's involves a complicated, interwoven s... (Leggi Articolo)
- National Cancer Institute has stopped a clinical trial of the Cox-2 inhibitor Celecoxib
- The FDA released the following statement on the halting of a clinical trial of the Cox-2 inhibitor Celebrex ( celecoxib ): The Food and Drug Administration (FDA) learned from the National Cancer Institute ( NCI ) and Pfizer, Inc., that NCI has stopped drug administration in an ongoing clinical... (Leggi Articolo)
- Cox-2 inhibitors: Bextra, boxed warning concerning severe skin reactions and warning regarding cardiovascular risk
- The FDA ( Food and Drug Administration ) announced important new information on side effects associated with the use of Bextra ( Valdecoxib ), a COX-2 selective non-steroidal anti-inflammatory drug ( NSAID ) which is indicated for the treatment of osteoarthritis, rheumatoid arthritis and dysmeno... (Leggi Articolo)
